Experimental Infection Using Mouse-Adapted Influenza B Virus in a Mouse Model
نویسندگان
چکیده
منابع مشابه
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
ISG15 functions as a critical antiviral molecule against influenza virus, with infection inducing both the conjugation of ISG15 to target proteins and production of free ISG15. Here, we report that mice lacking the ISG15 E1 enzyme UbE1L fail to form ISG15 conjugates. Both UbE1L(-/-) and ISG15(-/-) mice display increased susceptibility to influenza B virus infection, including non-mouse-adapted ...
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ژورنال
عنوان ژورنال: Viruses
سال: 2020
ISSN: 1999-4915
DOI: 10.3390/v12040470